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Saline Breast Implants vs. Silicone Breast ImplantsDocShop.com Tip: The main difference between saline breast implants and silicone breast implants is the substance which is used to fill the implant pouch. In both cases, the pouch is made of silicone. However, in the case of a saline breast implant, the pouch is filled with a saline solution. In a silicone implant, the pouch is filled with a silicone gel substance.
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